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Characterization and prospective follow-up of newly diagnosed Indian diabetic subjects (Wellcome diabetes study - WDS)

Funded By: Initially funded by Wellcome Trust, London, UK now funded by K.E.M. Hospital Research Centre, Pune
Month & Year of Commencement:  Feb 1987
Period of Study:  It is a prospective study and recently 15-year follow-up has been completed
Current Status:  Completed

Principal Investigator: Dr. C.S.Yajnik, Director,Diabetes Unit, KEM Hospital and Research Centre,Pune,India
Co-Investigator: Prof. TDR Hockdey, Ex- Director, Radcliffe Infirmary, University of Oxford, UK
» Background
» Objectives
» Methodology and Design
» Results


Recently some studies carried out in India have reported that the diabetes and cardiovascular disease (CHD) are on rise in India. Current prevalence is estimated to be >13% in urban adults. In the year 2000 there were an estimated 20-25 million diabetic patients in India. It is projected that this number will rise to 60 million by the year 2025. Diabetes will also be the commonest risk factor for premature coronary deaths.

Current clinical practice of diabetes in India is based entirely on the Western model, which may not be wholly appropriate in view of very different biological, social and economic conditions. There is an urgent need to document natural history of type 2 diabetes in India and to define risk factors for diabetic tissue damage so that priorities in management can be better defined.


To study the incidence and predictors of diabetic tissue damage in newly diagnosed Indian type 2 diabetic subjects.


This study is designed to find out the potential risk factors of diabetic tissue damage among Indians. The main groups involved in the study are the newly diagnosed cases of type 2 diabetes and the age matched people without diabetes. Based on the results obtained so far, we conclude that Indians with type 2 diabetes are more at risk of heart disease. Normal people who became diabetic later in the study were overweight or had gained weight and had increased triglycerides levels in their blood. Therefore it is important to keep our weight under control and follow moderations in diet on regular basis.